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KMID : 0861020130280020017
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Korea Journal of Herbology
2013 Volume.28 No. 2 p.17 ~ p.23
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Effect of the Chizadochi-Tang on Hepatotoxicity of D-Galactosamine in Rats
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김진호:Kim Jin-Ho
정종길:Jeong Jong-Kil
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Abstract
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Objectives : To investigate the hepatoprotective effect of Gardeniae Fructus (Ga) and Glycine semen preparatum
(Gl) aqueous extract against D-galactosamine (D-GalN, 300㎎/㎏ body weight) was administered to the male Sprague Dawley (SD) rats.
Materials and Methods : The study was carried out on male SD rats (age matched, weight 250±10 g). Experimental groups (Exp) divided four : Normal group (Nor) was administered saline, Control (Con) group was only received D-GalN (300 ㎎/㎏) intraperitoneally. Exp was orally administered Ga (200 mg/kg; Ga group), Gl (700 mg/kg; Gl group), and Chizadochi-Tang (200 mg/kg+700 mg/kg, GG group) after D-GalN treatment during 14 days (n=6).
Results : D-GalN administration induced hepatotoxicity in rats which was manifested by increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) but decreased total cholesterol (HDL C) and triglyceride (TG). The serum TG concentrations were significantly increased (# p<0.05) in the Ga group compared with Con. AST and ALP activities were significantly decreased (# p<0.05) in the all experimental groups compared with Con. ALT activities were significantly decreased (# p<0.05) in the Ga group compared with Con. LDH activities were significantly decreased (# p<0.05) in the GG group compared with Con. On the light microscopic study, a number of vacuole were observed in the Con, but decreased in experimental groups.
Conclusion : Ga aqueous extract and Chizadochi-Tang extract possesses hepatoprotective potential, thus validating its use in alleviating toxic effects of D-GalN.
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KEYWORD
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D-galactosamine, Gardeniae Fructus, Glycine semen preparatum, hepatoprotective
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